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Sildenafil is actually a potent and selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5), that's to blame for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is analogous to that of cGMP and functions like a competitive binding agent of PDE5 in the corpus cavernosum, resulting in a lot more cGMP a